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235 A notable positive feedback loop amplifies TGF- signaling: TGF--induced Smad2/3 activation upregulates TGFBRAP1, which competitively binds TRI and prevents its degradation by Smurf1/2-mediated ubiquitination

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This study was stopped early due to the frequency and magnitude of the elevation in ALT in the treatment group relative to controls, although none of the participants expressed symptoms of liver disease

Laboratory supplies (e.g., syringes, bacteriostatic water, etc.) are not included