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Its active component (Ac-LKKTETQ) is a thymosin 4 fragment identified in analytical and anti-doping studies

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Tirzepatide activates GIP receptor with potency comparable to native GIP, but activates GLP-1 receptor with potency lower than native GLP-1

GLP-1R activation by retatrutide promotes glucose-dependent insulin secretion, suppresses glucagon during hyperglycemia, delays gastric emptying, and reduces appetite via CNS signaling