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The side effect profile appears similar to existing GLP-1 medications, with gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation being most common
Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury
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Dihexa's synaptogenic effects require activation of the c-Met receptor, as demonstrated by experiments using c-Met-specific short hairpin RNA (shRNA) which completely abolished Dihexa's capacity to induce spine formation
The efficiency of GSTM3 knockdown and GSTM3 overexpression compared to the NC cell lines were confirmed using qRT-PCR and western blot (Figures 2CE)
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