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An increase in function will not always correlate with a linear decrease in pain

In addition, given the inherent day-to-day variability in function in the frail target population as well as the presence of a host of concomitant conditions, the appropriate patient population to be studied remains to be defined, and demonstration of clinically meaningful efficacy may be difficult

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Its estimated that between 1.5 and 15% of people have a vitamin B12 deficiency, and many of them dont even realize it