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Currently, he has severe persisting neuropathy despite intramuscular injection of hydroxocobalamin on alternating days, and the use of pregabalin, amitriptyline and a morphine preparation

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For people in chronic states of nervous system dysregulation whether from ongoing life stressors, unresolved trauma, or a condition like mast cell activation syndrome (MCAS) this pathway can be a dominant driver of histamine overload