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To verify the role of FTO in the process of cellular disulfidptosis, researchers treated UM cells with the FTO inhibitor meclofenamic acid (MA) and found that the m 6 A level within cells was significantly restored, the expression level of SLC7A11 was markedly upregulated, and a series of typical disulfidptosis features, such as cell shrinkage and disruption of the actin cytoskeleton, appeared in the cells, strongly confirming that inhibiting FTO can induce tumor cells to undergo disulfidptosis [112]

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Thyroid evidence boundary Jastreboff 2023 ( NEJM , NCT04881760), Rosenstock 2023 ( Lancet , NCT04867785), Sanyal 2024 ( Nature Medicine , NCT04881760), and the posted TRIUMPH-1 and TRIUMPH-4 toplines did not publish targeted Free T3, Free T4, or TSH outcomes