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Contributions of the microbial hydrogen economy to colonic homeostasis
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Semaglutide is recommended as an option: As monotherapy when metformin is contraindicated or not tolerated, or In dual or triple therapy combinations when a GLP-1 receptor agonist is appropriate (for example, when further glucose control is needed and weight loss would be beneficial, or when other treatments are unsuitable)
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GLP-1RA therapy frequently reduces overall energy intake and may lower protein consumption [75]
An individualized approach with slower dose escalation and more frequent monitoring is appropriate for this population
