What we know about safety comes from extrapolating each compound's individual profile and applying first-principles pharmacology
Using insurance claims data collected between 2011 and 2024, the researchers compared women who continued taking GLP-1 medications into the first trimester with women who stopped the medications after becoming pregnant
Moreover, in a hyperglycemic ApoE gene knockout mouse model, liraglutide was found to inhibit atherosclerosis through an AMPK-independent mechanism, suggesting that GLP-1 receptor agonists may exert cardiovascular protective effects through multiple mechanisms ( FIGURE 3 Preliminary evidence also suggests that tirzepatide may confer cardiovascular benefits by improving lipid metabolism (e.g., lowering LDL cholesterol) and reducing inflammation (e.g., lowering C-reactive protein)
All the Risks of Prescription GLP-1s May Not Be Known A major study published in 2017 found that nearly 1 out of every 3 drugs approved by the Food and Drug Administration (FDA) have a new safety issues detected in the years after approval. To think we know all the side effects of synthetic GLP-1s right now would be unwise
However, using it solely for weight loss in individuals without diabetes is not typically recommended without proper evaluation, as it may come with potential health risks
Ozempic is tailored for type 2 diabetes management, while Wegovy is crafted for chronic weight management
