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Reported side effects from clinical practice: Contraindications: Pregnancy, breastfeeding, active cancer, and known hypersensitivity

[8] Absolute contraindications include prior hypersensitivity to cyanocobalamin, cobalt, or formulation excipients

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A diagnostic, therapeutic, metabolic, or clinical material

This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin which causes deficiency

Cyanocobalamin is popular and effective, but hydroxocobalamin might offer unique benefits