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The seven additional Phase 3 readouts expected this year will provide the larger safety database the FDA needs to make this determination
5 years of Farxiga usage: Weight loss: 5-8 pounds (maximum amount achievable) Total costs: $30,000 to $36,000 (self-pay) or $1,500 to $6,000 (with insurance coverage) Side effects: Permanent UTIs, recurring yeast infections, increased dehydration risk Outcome after discontinuation: Weight gain back within 3 to 6 months Elimination of diabetes: 0% only possible through managing symptoms Frequency: Every day for years (and potentially a lifetime) Bariatric surgery (one-time surgical procedure): Weight loss: 60-80% of excess body weight Total costs: $15,000 to $25,000 (self-pay), or insurance coverage is often available Side effects: Recovery period post-surgery (2-4 weeks) Long-term outcome: Physiological change
This is why advanced cardiometabolic evaluation may include blood pressure patterns, ApoB, LDL particle burden, lipoprotein(a), triglycerides, insulin resistance, inflammatory markers, body composition, and, when appropriate, imaging-based cardiovascular risk assessment
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Bloodbrain barrier leakage in patients with early Alzheimer disease