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published from January 1, 2010, to July 1, 2018
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Activated CAFs secrete cytokines such as IL-6 and TGF-, remodel the ECM to create physical barriers, and promote immune evasion through paracrine signaling (34)
A potential strategy for achieving complete and relapse-free tumor remission involves combining conventional chemotherapy to target the bulk of tumor cells with drugs that inhibit glutathione synthesis to eliminate TICs