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In 1992, exendin-4, which can stimulate insulin secretion, was isolated from Heloderma suspectum venom with 53% homology to mammalian GLP-1, and can resist DPP-4 degradation and has low renal clearance rate (Muttenthaler et al., 2021)

Short-acting GLP-1 analogs often result in fluctuating plasma concentrations, contributing to side effects and inconsistent therapeutic outcomes

Researchers may divide it into smaller research portionssuch as four 2.5mg aliquotsbut the total content remains the same

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

The common adverse reactions of GLP-1R agonists include gastrointestinal reactions, mainly loss of appetite, nausea, vomiting, diarrhea, abdominal pain, etc., primarily mild or moderate

The pathophysiological processes universally converge on progressive depletion of endogenous antioxidants (e.g., SOD) and ROS-mediated amplification of macromolecular damage and cellular dysfunction [100, 555]