Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2
Some studies report stable or slightly improved bone density with GLP-1 therapy, while others suggest potential decreases, particularly in the context of significant weight loss
There is no evidence that NAD IV therapy harms healthy kidneys when administered properly
The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida
Nausea and appetite suppression from early GLP-1 therapy can reduce your overall calorie and nutrient intake, which lowers blood volume and oxygen delivery to brain tissues temporarily
Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns