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FDA's own scientists recommended against it, citing inadequate physicochemical characterization, immunogenicity risk from aggregation and peptide-related impurities, and insufficient evidence of effectiveness

Furthermore, ANGPTL3 interacts with ApoA-I in HDL, which obstructs the reverse cholesterol transport capability of HDL, compounding its impact on lipid metabolism [135]

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Primary care physicians can guide appropriate referrals and timing based on symptom urgency

It is highly addictive and withdrawal symptoms may be severe (but rarely fatal in adults)

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