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5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch

Endocrine 66 , 157165 (2019)

Mendelian randomization analysis reveals a causal connection between altered triglyceride, cholesterol levels, and depressive phenotypes (So et al., 2021)

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Am J Health Syst Pharm

The variable region may reflect the adaptive changes of different species during the evolutionary process