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Some users prefer longer cycles of 16 to 20 weeks followed by proportionally longer off periods

By examining a variety of Bcr-Abl downstream signals including pAkt-S473, pS6K-T389 in the PI3K/Akt/mTOR pathway, and pStat5-Y694, we confirmed these signals similarly elevated in these two different transformed cells

175 MolonB.UgelS.Del PozzoF.SoldaniC.ZilioS.AvellaD.et al (2011)

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Of those, just one study was done on humans, with only 12 patients

They may be used as pharmacodynamic biomarkers of target engagement and treatment response in disease-modifying trials [14, 18,19, 20]