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Rossignol and Frye have performed a systematic review and meta-analysis to investigate the prevalence of mitochondria-associated genetic abnormalities in autistic children [35]

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In addition, upregulation of ABCB1 is associated with the transcriptional fusion of ABCB1 and SLC25A40, which was identified through whole-genome analysis in patients with high-grade serous ovarian cancer (HGSOC) who underwent prior chemotherapy and targeted therapy [28]

Together, these mechanisms have made the combination a significant area of interest within endocrinology, growth hormone physiology, metabolic research, and healthy aging studies

Heme oxygenase-2 (HO-2) as a therapeutic target: activators and inhibitors