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Gut (2009) 58(3):33746.10.1136/gut.2008.148932 130 KokrashviliZMosingerBMargolskeeRF

Individuals with multiple dysregulated pathways may require additional interventions to achieve optimal outcomes

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Gleason et al

Since then, its use has expanded into general anti-aging and metabolic medicine, where clinicians prescribe it off-label for visceral fat reduction, body composition improvement, and, more recently, cognitive support in older adults

Tesofensine is currently in phase 3 clinical trials with the FDA and supported by further research at Johns Hopkins University School of Medicine