Glaeser, D
Changes in blood sugar patterns, eating behaviors, and energy levels all feed back into mood regulation, creating a complex interaction rather than a direct drug effect
On the other hand, protein restriction reduces nitrogen waste and helps decrease kidney workload by lowering pressure in the capillaries of the kidneys filtration system
What they did: n = 30 healthy middle-aged and older adults (55 to 79 years)
Assuming everyone took it, made no lifestyle changes and gained back more than half of the weight after discontinuation with no use as a maintenance drug afterwards, utilizing a very pessimistic penetration rate of 15%, even then it would be enough to have the obesity rate correct lower by more than 6%
Some emerging technologies, like microneedle-style patches, might eventually offer a more direct way to deliver medication