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Consider adding electrolyte supplements or drinking electrolyte-enhanced water if GI symptoms persist

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FDA prescribing information Wegovy (semaglutide) Most common adverse reactions for semaglutide 2.4 mg including nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, and injection-site reactions

There's no single answer to this question, so instead, let's look at some various considerations, potential timelines, and options you can consider

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Semaglutide can cause nausea and vomiting, and if Zofran does not fully prevent these symptoms, dehydration can become a serious issue