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The documented effects are local skin reactions irritation and the less common allergic contact dermatitis plus the procedural risks of microneedling where it's used as a delivery aid
(2015) Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reaction protein, and other cardiovascular risk factors: a randomized controlled trial
Stability is also influenced by temperature variations
Why B12 is important
Some patients continue with weekly injections for 6 months or longer, then transition to biweekly or monthly maintenance
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