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A 2023 systematic review and meta-analysis published in the Journal of Clinical Medicine found that semaglutide reduced systolic blood pressure by approximately 5 mmHg and diastolic blood pressure by about 2.5 mmHg in patients without diabetes
US Food and Drug Administration (2022)
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What to do if you are on a GLP-1 and want to keep muscle If you are taking a GLP-1 medication and worried about muscle loss, the answer is structure
Trends in Pharmacological Sciences, 46 (2), 101112
Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of every GLP-1 compound), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) map the baseline metabolic terrain any compound acts on
