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Symptoms of B12 Deficiency The symptoms of vitamin B12 deficiency can range from mild to severe and may include: - Fatigue and weakness - Anemia - Nerve problems like numbness and tingling - Balance issues - Cognitive difficulties, such as memory loss or difficulty thinking clearly - Mood changes, including depression - Skin problems, such as jaundice (yellowing of the skin) or a sore tongue Recognizing these symptoms early can lead you to consider B12 supplementation, but which form is the best for you