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The original goal of the staple was to get the peptide into the cell, but it turns out the staple can also enhance the binding and enhance the specificity, Keating says

Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats

Andrew Huberman, a neuroscience professor at Stanford, has stated publicly that "BPC-157 is one of the more interesting peptides because of the gastric juice origin and the acid stability, but the lack of human trials is a real limitation that people tend to overlook." This sentiment reflects the tension between preclinical promise and clinical evidence gaps

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