Cephalalgia 38(8):14711484 Tamborlane WV, Barrientos-Prez M, Fainberg U, Frimer-Larsen H, Hafez M, Hale PM, Jalaludin MY, Kovarenko M, Libman I, Lynch JL, Rao P, Shehadeh N, Turan S, Weghuber D, Barrett T (2019) Liraglutide in Children and Adolescents with Type 2 Diabetes
Individuals received a condition flag if they had one or more claims/encounters that matched a respective ICD-10 code mapped onto one of the Bridge clinical criteria in an inpatient, outpatient, carrier, home health, or skilled nursing facility setting in 2023
Key Takeaways Tirzepatide vs semaglutide comes down to dual agonist vs single agonist: tirzepatide targets both GLP-1 and GIP receptors, while semaglutide targets GLP-1 alone The only head-to-head trial (SURPASS-2) found tirzepatide superior to semaglutide for both blood sugar control and weight loss In separate obesity trials, tirzepatide 15mg achieved 20.9% weight loss at 72 weeks vs semaglutide 2.4mg's 14.9% at 68 weeks Semaglutide has proven cardiovascular benefit (SELECT trial: 20% MACE reduction)
In studies with rodents, GLP-1s caused thyroid tumors, including thyroid cancer
GentleCure IGSRT (Image-Guided Superficial Radiotherapy) , a non-surgical treatment that uses targeted radiation to treat skin cancer without cutting or scarring
I mean, the people who declined to do this experiment would probably have drunk different amounts than those who agreed, right