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The normalization was accompanied by increases in insulin and lowering of glucagon plasma concentrations, both of which returned to the original levels as glucose concentrations were getting normalized, illustrating the glucose dependency and safety (with respect to hypoglycaemia) of the GLP-1 infusion

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The rationale is that even sub-therapeutic doses activate the GLP-1 and GIP receptors enough to produce noticeable appetite modulation without the gastrointestinal side effects that trouble many users during standard initiation