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Benfotiamine, a fat-soluble thiamine homolog, is a synthetic S-acyl derivative of thiamine that has been shown to block three major pathways of hyperglycemia-induced microvascular damage [110]
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Its metabolism depends on hepatic binding proteins that selectively retain alpha-tocopherol from food for its incorporation into very low-density lipoproteins and its subsequent tissue distribution, together with esterified cholesterol and triglycerides 31
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