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Subjects were considered generally healthy based on medical history, physical examination, electrocardiogram and clinical laboratory tests
For a 50-year-old female with obesity, type 2 diabetes, and hypertension who is currently taking tirzepatide (Mounjaro) 12.5 mg weekly, phentermine 37.5 mg daily, losartan 50 mg, and spironolactone 50 mg, is it appropriate and safe to increase tirzepatide to 15 mg, continue phentermine for another month, and maintain her current antihypertensive regimen?
These variations don't predict toxicity alone but collectively inform personalized dosing guidance and risk stratification that providers should consider during clinical assessment
Worse yet, a 2024 study suggests that TB-500 itself may not even be the active compound, but that its healing activity might come from a smaller piece it breaks down into in the body
Some studies comparing tirzepatide and semaglutide over 72 weeks found that tirzepatide was more effective in reducing body weight and waist circumference
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