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But so far, no studies have proven whether this is the case
One study found that a weekly 2.4 mg dose led to a 20% reduction in major adverse cardiovascular events such as heart attack, stroke, or death among overweight or obese patients with existing cardiovascular disease, compared with a control group
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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
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