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In humans, these vitamins increased the diversity of microbiota compared to their deficiency [8, 139], improved TJ [8, 140, 141], inhibited the production of IFN- by T cells [8, 142] and inhibited Th17 cells and promoted the synthesis of IL-10 and FOXP3 protein [8, 143]

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This hypothesis was rooted in observing possible improvements in several key areas of wound healing

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This property distinguishes it from many other therapeutic compounds that require precise local delivery