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Krumholz HM , Nuti SV, Wang Y

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6, 7, 8 However, it is unclear whether H3K27me3 loss is specific for malignant peripheral nerve sheath tumor, as loss of this protein has also been reported recently in some other sarcomas, especially synovial sarcoma and dermatofibrosarcoma protuberans, and in other malignant spindle cell tumors (rare subset of spindle cell melanoma)

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Precautions : Avoid in patients with a history of medullary thyroid carcinoma or MEN2