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The anticipated incidence of the primary outcome (MALE) was low (e.g., less than 1%), and therefore participants in the GLP1RA and SGLT2i groups were matched at a 1:4 ratio to increase the statistical power

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Summary: Osmotic laxatives such as macrogol (Movicol, Laxido) or bulk-forming laxatives like ispaghula husk (Fybogel) are generally preferred first-line treatments for GLP-1-related constipation in the UK

Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, et al