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The role of miR-126 in the pathogenesis of MASLD is complex

Hydration Levels: Dehydration can sometimes be mistaken for hunger, potentially masking the effects of the medication

How to treat it: Apply a cold compress (wrapped in a cloth, not directly on skin) for 510 minutes before and after the injection

In practice, this means: No persistent nausea or vomiting for at least 7 consecutive days at the end of the current phase No ongoing diarrhea or significant GI discomfort that impacts daily functioning You are in week 4 or later at the current dose level (the 4-week minimum is absolute) If any of those conditions are not met at week 4, you are not ready to escalate