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Smoking is associated with elevated low-density lipoprotein cholesterol, decreased high-density lipoprotein cholesterol, increased blood catecholamine levels, increased fibrinogen levels, and impaired vascular endothelial function [36,37,38,39,40,41,42,43,44,45,46,47,48]

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(iii) the branched-chain -ketoacid dehydrogenase complex that is involved in the decarboxylation of ketoacids in the catabolic pathway of the branched-chain amino acids, namely leucine, isoleucine, and valine