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In June 2015, the FDA warned that the type 2 diabetes medicines Sitagliptin (and saxagliptin, linagliptin, and alogliptin) may cause joint pain, which can be severe and disabling

That analysis came from a relatively small subpopulation of just 55 patients who underwent whole-body MRI scanning, which showed that the reduction in lean muscle mass with treatment, which raises concerns about loss of physical strength, mobility, and metabolic health, was around 10%

Wear sunscreen Some research suggests that regular sunscreen use prevents skin ageing

GLP-1 medications should be stored in the refrigerator at 36F to 46F (2C to 8C) until first use

The animal data offers a partial explanation

However, retatrutide is most effective at reducing fat mass