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The phase 2 combination trial in type 2 diabetes Frias et al
Importantly, we established that ultrafiltered flavan-3,3,4-triol (4 ) was converted to cyanidin ( 8 ) by additional well-characterized arGSTs from maize ( Zm BZ2), arabidopsis ( A tTT19) and grapevine ( Vv GST4), and from the structure-elucidated phi-class orthologue from poplar ( Pt GSTF8), while application of GSTs unrelated to anthocyanin biosynthesis ( Vv GST2, Vv GST5, At GSTF2) did not result in cyanidin ( 8 ) formation (Fig
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Studies have found that in the retinal tissue of DR patients, high glucose can induce upregulation of NCOA4 expression, enhance ferritinophagy, reduce FtL, increase LC3-II/I, and activate NOX to produce ROS, forming a ROS ferritinophagy-free iron positive feedback loop (172)
Heerspink HJL et al
