Albiglutide Harmony outcomes was a double-blind trial that included a total of 9,463 T2D participants of 40 years of age and a history of CVD, who were allocated to an albiglutide (3050 mg weekly) group or placebo group ( Renoprotection of GLP-1RAs is Largely Dependent on Reduction of Albuminuria As described above, GLP-1RAs have no clinically important effect on eGFR and hard renal endpoints
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Additional ongoing studies target JAK/STAT signaling with SHR-0302 and SHR-2554 (NCT06519526), as well as agents modulating the Notch (e.g., MK-0752, NCT00106145), Hippo (e.g., IK-930, NCT05228015), and GAS6/AXL (e.g., bemcentinib, NCT02424617) pathways in a variety of advanced or resistant tumors