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Over the past few years, however, they have surged in popularity, largely because of their remarkable effectiveness for weight loss

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Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G, et al

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Contrave, designed for oral administration, has variable bioavailability: naltrexone reaches about 96% bioavailability, while bupropion achieves approximately 87% bioavailability when taken with food

This includes individuals engaging in regular exercise and calorie-controlled diets