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177,178 In conclusion, mitochondria activate NLRP3 inflammasome and initiate inflammatory response through diversified mechanisms including mtDNA leakage, ROS production, ATP, mitophagy and interaction with lysosomes

Studies support that carboxypeptidase A (CPA), a pancreas-derived exo-protease with specificity for C-terminal aromatic and aliphatic amino acid residues, is responsible for the removal of L585 60,63,64,65

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Further studies showed that different subtypes of T cells had apparently different effects on microglia

Investigate whether disease progressing despite peptides requiring conventional treatment intensification