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The side-chain conformations cluster at the staggered positions, and show well-defined preferences
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Safety data from animal studies supports human research applications
L-carnitine used by itself or in combination with clomiphene citrate may help treat idiopathic male infertility (25) and reduce lower urinary tract symptoms in those with benign prostatic hyperplasia (67) although it did not improve sperm count or motility (40)
To evaluate the functional relevance of the GLP-1R cholesterol binding sites identified during the cgMD simulations, 12 residues were selected within or at the periphery of these sites and mutated to alanine by site-directed mutagenesis (Figure 2F)
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