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This is because the metformin component is cleared by the kidneys, and impaired function can lead to a buildup of the drug, increasing the risk of lactic acidosis

Regarding gonadal effects, treatment with GLP1/E, GLP1/GIP, and metformin did not alter ovarian or uterus weights, nor did they change circulating LH levels in this hyperandrogenic model of PCOS (Suppl

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