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Physiol Behav 229:113252
Primarily, prescription drugs benefit from rigorous clinical validation, ensuring higher efficacy and safety profiles than Over-the-Counter (OTC) alternatives
Tirzepatide adds to the growing list of diabetes medications that may also facilitate weight loss and have been used off-label for weight loss in patients without type 2 diabetes.
its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust ( Finally, insurmountable technical barrierssuch as inability to manufacture stable formulations, extreme immunogenicity, or lack of feasible delivery routesmay justify abandonment independent of biological plausibility
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