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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

The gap between the volume of anecdote and the volume of human evidence is real

Thymosin Beta-4 was first isolated in the 1960s from thymus extracts

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Human obesity studies were also conducted during pharmaceutical development, but the largest reported placebo-controlled study did not demonstrate a statistically significant weight-loss benefit, and development for obesity was discontinued