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Some clinical trials report that DPP-4 inhibitors improve heart failure symptoms (133), while other studies suggest that their cardiac protective effects are limited (134)
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Sphincter recovery often occurred alongside improvement in brain lesions and normalization of intracranial pressures in multi-system injury models
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GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)
doi: 10.1128/MMBR.00045-10 368 SharmaM.ManoharlalR.NegiA
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