Potential Effects on Thyroid Function Impact on Thyroid Hormone Levels The relationship between GLP-1 agonist and thyroid function has garnered attention due to concerns about their potential impact on thyroid hormone levels
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However, if investigations reveal thyroid dysfunction, anaemia, or nutritional deficiencies, these can be treated appropriately whilst continuing GLP-1 therapy if clinically indicated
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The mechanism is multifactorial: weight loss reduces blood volume and vascular resistance, improved insulin sensitivity reduces sodium retention, and direct GLP-1 receptor effects on renal sodium handling
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