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Spermidine synthase is encoded by the SRM gene (also known as SPDSY) which is located on chromosome 1p36.22 and is composed of 8 exons that encode a protein of 302 amino acids
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Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity
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Reduced manganese superoxide dismutase (MnSOD) activity, reduced glutathione to glutathione disulphide (GSH/GSSG) ratios, and an impaired oxidative phosphorylation system were accompanied by an increase in caspase 9 activity in hippocampal homogenates
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