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In pathological conditions, astrocytes undergo significant molecular and morphological remodeling, adopting either a detrimental A1 (neurotoxic) or beneficial A2 (neuroprotective) reactive state that, respectively, drives injury progression or promotes tissue repair [132, 133]
The lifelong effects of early childhood adversity and toxic stress
Fouad YA, Aanei C (2017) Revisiting the hallmarks of cancer
However, with age, pollution, stress, and UV exposure, the natural production of glutathione declines in the body
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