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All these disorders share the following pathophysiological features: amyloid accumulation, tau hyperphosphorylation, cerebral vasculopathy, inflammation, and oxidative stress in the CNS
The physiological effects of GLP-1 include stimulating insulin secretion in a glucose-dependent manner (Holz Iv et al 1993), inhibiting glucagon release, and slowing gastric emptying
Pseudomonas (some)
It may take 3 to 5 weeks of treatment for symptoms to improve
Insulin resistance (IR), commonly associated with obesity, disrupts these processes
In two cases, the disease-causing variant remained undetermined
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