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Kolotkin RL, Crosby RD, Kosloski KD, Williams GR
There is no clinical penalty for a slower escalation
Many patients experience transient changes in bowel frequency that improve within several weeks as the body adapts to the medication
Follow-up Repeat broad and inflammation markers after 6-12 weeks if symptoms change or the protocol continues
Animal studies show 15-25% increases in muscle mass over 4-6 weeks at doses of 50-150 mcg/kg/day
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