Rewiring urea cycle metabolism in cancer to support anabolism
NQO1 is a flavoenzyme responsible for the two-electron reduction of a wide range of quinones to stable hydroquinones
While on the topic of skin, it is impossible not to mention Marine Collagen as a staple of skin health as we age, which has been proven to enhance skin hydration, elevate elastin levels, and promote overall skin immunity
Notably, inhibition of MAPK/ERK signalling exacerbates 3-HK-induced mitochondrial dysfunction and cell death, implicating impaired cellular resilience pathways in amplifying KYN-mediated toxicity
For skin health, at our Naturopath Clinic, we usually administer 2 - 4 grams of Glutathione, 1-2x weekly for 4-12 weeks, usually with 5-10grams of Vitamin C
While sometimes this is necessary to prevent discomfort and/or mastitis, be cautious not to inadvertently encourage increased production